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KMID : 1145520190050020071
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Journal of Radiopharmaceuticals and Molecular Probes
2019 Volume.5 No. 2 p.71 ~ p.78
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Comparative study of 82Sr separation/purification methods used at Brookhaven National Laboratory and ARRONAX Laboratory and ARRONAX
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Ha Yeong-Su
Yoon Sang-Pil
Kim Han-Sung
Kim Kye-Ryung
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Abstract
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Nuclear imaging is one of the most powerful measures for non-invasive diagnosis of myocardial vasculardisease. Radionuclide such as 13N, 15O, 201Tl and 82Rb is used for the measurement of cardiac blood flow.
13N, 15O and 201Tl are produced in cyclotrons while 82Rb is obtained from generator. Rubidium (Rb), an alkaliion, behaves biologically like potassium, and accumulates in myocardial tissue. Rb has rapid blood clearanceprofile which allows the use of 82Rb with a short physical half-life of 75 s for non-invasive evaluation of regionalmyocardial perfusion. There are several advantages of 82Rb over other radioisotopes. An ultra-short half-lifesignificantly reduces the exposure of patients to radiation and allows to repeat injections for studying the effectsof medical intervention. As a positron emitter, 82Rb allows positron emission tomography (PET) imaging whichhave shown superior diagnostic performances. 82Rb can be produced from generator by decay of its parent82Sr. However, the preparation of 82Sr is difficult, because appropriate purity is required to meet the specificationof the product. Recently reported procedure from ARRONAX research institute showed that a Chelex-100 resinis sufficient for this purpose and additional column is not necessary. Whereas Brookhaven National Laboratory(BNL) procedure contains three ion exchange resin separation, including Chelex-100 resin. Currently, since82Sr production site is non-existent in Korea, Korea Atomic Energy Research Institute (KAERI) has plan toproduce 82Sr within specifications. We compared 82Sr purification procedures reported from ARRONAX andBNL to investigate the most suitable procedure for our conditions.
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KEYWORD
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Strontium-82, Rubidium-82, Generator, Myocardial perfusion imaging, Purification, Ion-exchange resin
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